OSA is linked to increased risk for non-Hodgkin lymphoma

  • Choi JH & al.
  • Leuk Res
  • 15 Sep 2020

  • curated by Miriam Davis, PhD
  • Clinical Essentials
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Obstructive sleep apnea (OSA) is associated with an increased incidence of non-Hodgkin lymphoma (NHL).
  • Results are based on data from the Korean National Health Insurance Service covering more than 2 million people.

Why this matters

  • OSA may be a modifiable risk factor for NHL.

Study design

  • Retrospective cohort study comparing all patients aged ≥20 years who made an OSA-related claim (n=198,574), propensity age- and sex-matched with those who did not (n=992,870), during the same period (2007-2014).
  • Patients and control participants were followed for the incidence of NHL.
  • Funding: None disclosed.

Key results

  • Follow-up was 4.8±2.3 years.
  • The incidence of NHL was increased by 40% in patients with OSA vs control participants (HR, 1.40; 95% CI, 1.16-1.69).
  • The HR was somewhat higher for women (1.62; 95% CI, 1.07-2.38) vs men (1.28; 95% CI, 1.03-1.59).
  • The groups did not differ regarding age.

Limitations

  • Retrospective, observational.