Pediatric influenza vaccine: efficacy not diminished by prior vaccination

  • JAMA Network Open

  • curated by Liz Scherer
  • Clinical Essentials
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Prior season vaccine effectiveness (VE) is not associated with reduced current VE/vaccine failure in children.

Why this matters

  • Per Advisory Committee on Immunization Practices (ACIP) recommendations, annual influenza vaccination is strongly recommended in children.

Key results

  • 3369 children, 50% unvaccinated, 34%, 15% received inactivated influenza vaccine (IIV), live attenuated influenza vaccine (LAIV), respectively, per enrollment season.
  • A(H1N1): IIV VE was 72.4% (95% CI, 56.0%-82.7%), 67.5% (95% CI, 32.1%-84.4%) among children with, without prior season vaccination, respectively; LAIV VE was not associated with (47.5% [95% CI, 11.4%-68.9%] or without (7.8% [95% CI, −101.9% to 57.9%]) prior season vaccination.
  • A(H3N2): IIV VE was 38.7% (95% CI, 6.8%-59.6%), 23.2% (95% CI, −38.3% to 57.4%) for vaccinated in prior season, unvaccinated, respectively.
  • LAIV VE differed by prior season vaccine status (50.3% [95% CI, 17.0%-70.2%], −82.4% [95% CI, −267.5% to 9.5%], respectively, for vaccinated, unvaccinated in 1 prior season (P<.001 vaccine type vs receipt of iiv laiv prior season respectively p=".001).</li">
  • Influenza B: VE was >50% for prior LAIV, IIV vaccination history.

Study design

  • Test-negative, case-control, post hoc, multiseason analysis evaluating association of prior season vaccination and VE, and influenza risk among vaccinated children ages 2-17 years by vaccine type received.
  • Funding: None disclosed.

Limitations

  • Small sample sizes.
  • Residual confounding.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit