- In this cohort study of children with obstructive sleep apnea (OSA), earlier diagnosis and more severe disease suggested a higher likelihood the condition would persist into adulthood.
- Authors urge pediatric obesity prevention, mitigation.
Why this matters
- OSA affects 3%-5% of children; etiology is commonly adenotonsillar hypertrophy.
- Few longitudinal data exist on natural history, and very few studies have followed children into adulthood.
- Mean ages at baseline, follow-up: 9.8, 20.2 years, respectively.
- Upon follow-up, among participants with baseline obstructive apnea-hypopnea index (OAHI) >1 event/hour:
- 30% (29/96) experienced complete remission, and
- 69% (66/96) had
- Upon follow-up, among those with baseline OAHI ≥5 events/hour (moderate-to-severe disease), 57% (12/21) had persistent disease.
- Diagnosis at age >10 years vs younger age predicted persistence into adulthood.
- OSA remission at follow-up predicted by female sex.
- Incident OSA at follow-up predicted by:
- Male sex;
- Higher baseline BMI z-score, or increase;
- OAHI >0; and
- Habitual snoring.
- Prospective community-based cohort study (n=243).
- For 10 years, authors followed children with OSA and unaffected controls, monitoring symptoms, growth, tonsil size, polysomnography.
- Outcome: associations with adult OSA and remission.
- Funding: Hong Kong Special Administrative Region.
- Potential selection bias.
- Unclear what later clinical significance resolved pediatric OSA might have.