Pediatric UC: study shows high rate of 5-ASA intolerance

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  • This study found a relatively high incidence of 5-aminosalicylate (5-ASA) intolerance; besides a challenge test, elevation of C-reactive protein (CRP) and positive drug-induced lymphocyte stimulation test (DLST) support diagnosis of 5-ASA intolerance.

Why this matters

  • 5-ASA is widely used as a first-line drug for ulcerative colitis (UC), but medication intolerance can cause exacerbations that mimic disease.

Key results

  • Among 80 children with UC, 11 (13.8%) were diagnosed with 5-ASA intolerance.
  • In patients not receiving corticosteroids, median duration between initiation of 5-ASA and onset of intolerance was 10 d...