- Fecal calprotectin (FCP) testing offers a noninvasive alternative to endoscopy with biopsy for diagnosing and monitoring ulcerative colitis (UC) disease activity.
Why this matters
- The test is simple and fast, and can be performed at the point of care without special equipment.
- Researchers studied patients with either active or quiescent UC undergoing colonoscopy (n=116; 55.17% men; mean age, 38.9±9 years; age range, 18-63 years), comparing them with a control group of patients with irritable bowel syndrome (IBS; n=36).
- They graded colonoscopy findings using the Mayo endoscopic score (EMS) and UC endoscopic index of severity (UCEIS) and analyzed FCP levels in stool samples collected within 2 days before colonoscopy.
- Funding: None.
- Researchers found no significant difference between mean FCP levels in the UC group and those in patients with IBS or in UC remission (P=.205).
- In contrast, mean FCP levels were significantly higher in patients with active UC (P<.001>
- Mean FCP levels correlated significantly with UCEIS (Pearson correlation coefficient [r]=0.869; P<.001 and ems p>
- The study was single-center with a small sample size.