- Patients with stage IIIA/N2 NSCLC with low diffusing capacity of the lung for carbon monoxide (DLco) before neoadjuvant concurrent chemoradiotherapy (CCRT) are significantly more likely to develop a postoperative pulmonary complication (PPC) after CCRT.
Why this matters
- CCRT followed by surgical resection is the standard treatment for stage IIIA/N2.
- 321 patients underwent CCRT followed by surgical resection for stage IIIA/N2 NSCLC.
- Funding: National Research Foundation of Korea.
- 24.6% developed ≥1 PPC.
- Compared with patients without PPC, those with PPC were more likely to:
- Be older: 63.3 vs 60.4 years (P=.006).
- Be male: 89.9% vs 77.7% (P=.017).
- Have a smoking history: 89.9% vs 77.3% (P=.014).
- Have undergone more extensive resection: 30.4% vs 16.9% (P=.010).
- Average DLco decrease after CCRT was 12.3%.
- PPC frequency was higher in patients with a low DLco before CCRT vs those with normal DLco: 35.3% vs 14.5% (P<.001>
- Risk increase for any PPC was significantly greater in patients with a low DLco before CCRT than those with normal DLco: incidence rate ratio, 2.14 (95% CI, 1.36-3.36).
- Single-center, retrospective study.