- Women who are both overweight and have a predisposition to diabetes mellitus (DM) have the highest risk for an adverse pregnancy complication.
Why this matters
- The combination of overweight and predisposition to DM may be synergistic.
- The highest frequency of cesarean delivery (CD) was 24.0% and was found among those with overweight/predisposition to diabetes.
- The highest frequency of large for gestational age (LGA) was 23.3%, also in this group
- Compared with controls, overweight alone was linked to increased risk for:
- LGA: 7.1% vs 2.9% without; and
- CD: 14.9% vs 10.1% without (P<.001 for both>
- Compared with controls, predisposition to diabetes alone was linked to increased risk for LGA: 11.6% vs 2.9% without (P<.001>
- Retrospective population-based cohort study (n=29,488).
- Cohort from a Swedish population register.
- Women ages 25-65 years who had pregnancy data were included (n=13,037).
- Predisposition to diabetes was defined as onset of diabetes after pregnancy.
- Cohort stratified into 4 groups: overweight; overweight plus predisposition to diabetes; normal weight and predisposition to diabetes; and controls.
- Funding: Research Funds in Region Skane; Medical Faculty, Lund; University Hospital in Lund; Swedish Cancer Society.
- No identification of predisposition to diabetes during pregnancy.