- A low ratio of maternal cortisol to cortisone is associated with preeclampsia and preterm fetal growth restriction (FGR) during pregnancy.
Why this matters
- Predictive factors can help guide patient management.
- At 28 weeks of gestational age, the cortisol/cortisone ratio was negatively associated with preterm preeclampsia (OR, 0.34; P<.001 term preeclampsia and preterm fgr in adjusted analysis. style="list-style-type:circle;">
- The negative association with preeclampsia was also observed in women who did not receive steroids antenatally (OR, 0.10 [P<.05 for preterm preeclampsia or term>
- The negative associated with term preeclampsia was also observed in women who did not receive steroids antenatally (OR, 0.41; P<.001>
- 658 pregnant women, 194 with preeclampsia, 185 with FGR, and 279 healthy control patients, were analyzed for maternal serum cortisol to cortisone ratio.
- Funding: National Institute for Health Research; Cambridge Comprehensive Biomedical Research Centre; Medical Research Council; GE Healthcare.
- Circadian rhythms and some other external factors not accounted for.