- A case-control study finds that pregnant women with polycystic ovary syndrome (PCOS) have elevated levels of antimüllerian hormone (AMH), testosterone, and androstenedione at term compared with control subjects.
- Differences were pronounced in pregnancies with a female fetus.
Why this matters
- This study suggests a hormonal imbalance in pregnant women with PCOS.
- Women with PCOS had higher median levels of AMH (1.61 vs 0.71 ng/mL; P<.001 testosterone vs nmol p=".027)," and androstenedione at term compared with control patients.>
- Women carrying female fetuses had lower levels of AMH (P<.05 testosterone and androstenedione compared with women carrying male fetuses. style="list-style-type:circle;">
- In women carrying female fetuses, levels of AMH (P<.01 testosterone androstenedione and estradiol were higher in women with pcos compared control patients.>
- In women carrying male fetuses, women with PCOS and control patients had similar levels of AMH, testosterone, androstenedione, and estradiol (P>.05 for all).
- 74 pregnant women, 25 with PCOS and 49 control patients, were analyzed for plasma AMH and steroid hormone levels.
- Funding: Sigrid Juselius Foundation; Finnish Medical Foundation.
- Small patient sample size.