Pregnant women with PCOS have elevated AMH and androgen levels at term

  • Piltonen TT & al.
  • Fertil Steril
  • 7 Jan 2019

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • A case-control study finds that pregnant women with polycystic ovary syndrome (PCOS) have elevated levels of antimüllerian hormone (AMH), testosterone, and androstenedione at term compared with control subjects.
  • Differences were pronounced in pregnancies with a female fetus.

Why this matters

  • This study suggests a hormonal imbalance in pregnant women with PCOS.

Key results

  • Women with PCOS had higher median levels of AMH (1.61 vs 0.71 ng/mL; P<.001 testosterone vs nmol p=".027)," and androstenedione at term compared with control patients.>
  • Women carrying female fetuses had lower levels of AMH (P<.05 testosterone and androstenedione compared with women carrying male fetuses. style="list-style-type:circle;">
  • In women carrying female fetuses, levels of AMH (P<.01 testosterone androstenedione and estradiol were higher in women with pcos compared control patients.>
  • In women carrying male fetuses, women with PCOS and control patients had similar levels of AMH, testosterone, androstenedione, and estradiol (P>.05 for all).

Study design

  • 74 pregnant women, 25 with PCOS and 49 control patients, were analyzed for plasma AMH and steroid hormone levels.
  • Funding: Sigrid Juselius Foundation; Finnish Medical Foundation.

Limitations

  • Small patient sample size.

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