- Preterm and early-term birth are strong risk factors for the development of chronic kidney disease (CKD) in childhood through midlife.
Why this matters
- Preterm birth interrupts a critical period of kidney development and results in fewer nephrons, which has been tied to later hypertension and kidney disease.
- Analysis of 4,186,615 single live births in Sweden during 1973-2014, cross-matched with CKD cases from nationwide medical records through 2015.
- Funding: NIH, Swedish Research Council, Swedish Heart-Lung Foundation, ALF project grant.
- 4305 individuals aged 0-43 years (0.1%) developed CKD (incidence rate, 4.95 per 100,000 person-years [PY]).
- CKD incidence rate for full-term birth, 4.47 per 100,000 PY (reference).
- CKD risk from birth to midadulthood vs full-term (4.47 per 100,000 PY):
- Preterm (
- Extremely preterm (
- Early-term (37-38 weeks): aHR=1.30; P<.001 per py.>
- Association was strongest up to age 9 years (aHR=5.09; P<.001 style="list-style-type:circle;">
- Risk weakened but remained elevated at ages 10-19 years (aHR=1.97; P<.001 and years p>
- Observational design.
- Lack of detailed CKD data.