PTC: increased risk for young and elderly patients

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Takeaway

  • Age <25 or >75 y is associated with high-risk histopathologic features in patients with papillary thyroid cancer (PTC).

Why this matters

  • Identifying high-risk features might help stratify patient care.

Key results

  • Patients <25 y had higher rates of extranodal extension compared with patients 25-44 y (20% vs 5%; P=.002).
  • Patients <25 y had higher rates of vascular invasion and lymph node metastasis compared with patients aged 45-75 y (23% vs 10% [P<.001] and 45% vs 22% [P=.001], respectively).
  • Patients >75 y had higher rates of vascular invasion and extrathyroidal extension compared with patients aged 45-75 y (26% vs 6% [P<.001] and 45% vs 19% [P=.001], respectively).
  • Patients >75 y had higher rates of extrathyroidal extension compared with patients aged 25-44 y (45% vs 15%; P<.001).

Study design

  • 632 patients with PTC were analyzed for associations between age and aggressive histopathologic features.
  • Funding: None disclosed.

Limitations

  • Small patient sample size for recurrences (n=25).
  • Retrospective study from single institution.