Residual cardiovascular risk: management beyond statins

Access to the full content of this site is available only to registered healthcare professionals. Register to read more

Statins represent the cornerstone for lowering low-density lipoprotein cholesterol (LDL-C) to prevent cardiovascular disease (CVD). However, it is clear that even with potent statin therapy, a high risk of CVD events persists, especially in individuals with cardiometabolic disease.

Other lipids and lipoproteins have been implicated as contributors to this risk. There is emerging evidence to support a role for elevated triglyceride-rich lipoproteins and remnants (with or without low high-density lipoprotein cholesterol [HDL-C]), especially in individuals with insulin-resistant conditions.  The role of HDL-C itself is contentious. Although low HDL-C plasma concentration is established as a risk factor for coronary heart disease, thereby providing a firm basis for integration of HDL-C levels into the SCORE charts for global CV risk assessment, recent trials of HDL-raising a...