Screen for atrial fibrillation in patients with Parkinson's disease

  • Hong CT & al.
  • Front Neurol
  • 1 Jan 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • People with Parkinson’s disease were more likely to be comorbid with atrial fibrillation before and during the onset of motor symptoms.
  • Patients with Parkinson’s disease were at a lower risk for atrial fibrillation in the later stages of the disease.

Why this matters

  • Individuals with or at high risk for Parkinson’s disease should be screened for atrial fibrillation regularly.

Study design

  • In total, 15,375 patients with newly diagnosed Parkinson’s disease and matched controls (n=4,603,858) were followed up for their risk for atrial fibrillation.
  • Funding: None.

Key results

  • Newly diagnosed people with Parkinson’s disease were significantly comorbid with atrial fibrillation (aOR, 1.15; 95% CI, 1.04-1.28).
  • Newly diagnosed people with Parkinson’s disease had a lower risk for atrial fibrillation during the follow-up period (adjusted subdistribution HR, 0.92; 95% CI, 0.86-0.98).
  • In subgroup analysis, people aged ≥65 years (aOR, 1.16; 95% CI, 1.04-1.29) and women with Parkinson’s disease (aOR, 1.20; 95% CI, 1.01-1.41) were at higher risk for atrial fibrillation.
  • Subgroup analysis showed that this association consistently presented in the absence of confounding factors of atrial fibrillation.

Limitations

  • Retrospective design

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