- People with Parkinson’s disease were more likely to be comorbid with atrial fibrillation before and during the onset of motor symptoms.
- Patients with Parkinson’s disease were at a lower risk for atrial fibrillation in the later stages of the disease.
Why this matters
- Individuals with or at high risk for Parkinson’s disease should be screened for atrial fibrillation regularly.
- In total, 15,375 patients with newly diagnosed Parkinson’s disease and matched controls (n=4,603,858) were followed up for their risk for atrial fibrillation.
- Funding: None.
- Newly diagnosed people with Parkinson’s disease were significantly comorbid with atrial fibrillation (aOR, 1.15; 95% CI, 1.04-1.28).
- Newly diagnosed people with Parkinson’s disease had a lower risk for atrial fibrillation during the follow-up period (adjusted subdistribution HR, 0.92; 95% CI, 0.86-0.98).
- In subgroup analysis, people aged ≥65 years (aOR, 1.16; 95% CI, 1.04-1.29) and women with Parkinson’s disease (aOR, 1.20; 95% CI, 1.01-1.41) were at higher risk for atrial fibrillation.
- Subgroup analysis showed that this association consistently presented in the absence of confounding factors of atrial fibrillation.
- Retrospective design