- Exposure to secondhand smoke is tied to an increased risk for chronic kidney disease (CKD) among nonsmokers.
Why this matters
- According to CDC, ~58 million nonsmokers in the US were exposed to secondhand smoke during 2011-2012.
- Study of 131,196 nonsmokers (mean age, 53±8 years; 75% women) participating in the 2001-2014 Korean Genome and Epidemiology study, stratified by exposure level (none [n=114,502],
- Mean estimated glomerular filtration rate (eGFR), 92±14 mL/minute/1.73 m2.
- Funding: Ministry for Health and Welfare, Korea; Inha University Hospital.
- Baseline CKD (eGFR 2), rates: 1.8% with high secondhand smoke exposure, 1.7% with low exposure, and 2.0% with no exposure.
- Odds of baseline CKD was 48% higher with secondhand smoke exposure vs no exposure (aOR=1.48; 95% CI, 1.25-1.74):
- Low exposure: aOR=1.72 (95% CI, 1.30-2.27).
- High exposure: aOR=1.44 (95% CI, 1.22-1.70).
- In a longitudinal subgroup (n=1948, 80% with exposure), rate of incident CKD was 16.4% over a mean follow-up of 8.7 years.
- Risk for CKD development was 64% higher with secondhand smoke exposure (aHR=1.64; 95% CI, 1.03-2.60) vs no exposure:
- Low exposure: aHR did not reach statistical significance.
- High exposure: aHR=1.66 (95% CI, 1.03-2.67).
- Small sample size in low exposure group.
- Secondhand smoke not quantified.
- Renoprotective/toxic medications not captured.