- Progression of emphysema is more rapid among men with COPD and the most severe baseline level of plasma 25-hydroxyvitamin D (25-OHD).
Why this matters
- This study is 1 of the first to examine the effect of 25-OHD deficiency on emphysema progression.
- Findings suggest that male patients with COPD should have 25-OHD levels monitored and receive supplementation if indicated.
- Prospective cohort (Korean Obstructive Lung Disease Cohort) study comparing emphysema progression in relation to baseline 25-OHD blood levels in men (n=151; too few women participated for analysis).
- Emphysema progression was assessed annually over a 3-year period by increases in the CT emphysema index (% of the lung
- Patients were classified at baseline into 4 subgroups of 25-OHD levels: sufficiency (≥20 ng/mL), mild deficiency (15-20 ng/mL), moderate deficiency (10-15 ng/mL), and severe deficiency (
- CT emphysema index at baseline was independently associated with significant differences among the 4 25-OHD subgroups (P=.034), as was the CT emphysema index over 3 years (P=.047).
- The severe 25-OHD deficiency group had a higher annual increase in the CT emphysema index (1.34% per year) than the other 25-OHD groups (0.41% per year; P=.003).
- Only 1 measure of 25-OHD.
- Observational design.