Severe vitamin D deficiency tied to faster emphysema progression in COPD

  • Respir Med

  • curated by Miriam Davis, PhD
  • Clinical Essentials
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Takeaway

  • Progression of emphysema is more rapid among men with COPD and the most severe baseline level of plasma 25-hydroxyvitamin D (25-OHD).

Why this matters

  • This study is 1 of the first to examine the effect of 25-OHD deficiency on emphysema progression.
  • Findings suggest that male patients with COPD should have 25-OHD levels monitored and receive supplementation if indicated.

Study design

  • Prospective cohort (Korean Obstructive Lung Disease Cohort) study comparing emphysema progression in relation to baseline 25-OHD blood levels in men (n=151; too few women participated for analysis).
  • Emphysema progression was assessed annually over a 3-year period by increases in the CT emphysema index (% of the lung
  • Patients were classified at baseline into 4 subgroups of 25-OHD levels: sufficiency (≥20 ng/mL), mild deficiency (15-20 ng/mL), moderate deficiency (10-15 ng/mL), and severe deficiency (

Key results

  • CT emphysema index at baseline was independently associated with significant differences among the 4 25-OHD subgroups (P=.034), as was the CT emphysema index over 3 years (P=.047).
  • The severe 25-OHD deficiency group had a higher annual increase in the CT emphysema index (1.34% per year) than the other 25-OHD groups (0.41% per year; P=.003).

Limitations

  • Only 1 measure of 25-OHD.
  • Observational design.