- Sickle cell disease (SCD) is associated with a rapid decline in estimated glomerular filtration rate (eGFR) over time.
Why this matters
- Decline is sharper with more severe disease forms, such as sickle cell anaemia (HbSS) or sickle β0 thalassaemia (HbSβ0).
- Traditional risk factors play a key role in milder forms (haemoglobin SC disease [HbSC], sickle β+ thalassaemia [HbSβ+]).
- Cohort study of 427 patients with SCD; 331 had ≥2 creatinine measurements.
- Most common forms were HbSS (63.0%) and HbSC (23.0%).
- Median follow-up, 4.01 years.
- Funding: US National Heart, Lung, and Blood Institute.
- Baseline chronic kidney disease (CKD) was more common in severe vs mild genotypes (21.4% vs 17.2%).
- Annual eGFR decline:
- 2.05 mL/min/1.73m2 for severe genotypes (P<.001>
- 1.16 mL/min/1.73m2 for mild genotypes (P=.02).
- Rate of eGFR decline was associated with factors such as diabetes and blood pressure.
- Retrospective, observational, monocentric design.