Takeaway
- Smokers undergo percutaneous coronary intervention (PCI) at a much younger age and more commonly for acute coronary syndrome (ACS) vs never-smokers.
- Current smoking is associated with increased 30-day mortality.
- Ex-smokers and never-smokers have similar presentation age for PCI, and there is no short (30-day) or intermediate (30-day to 6-month) mortality difference between them following PCI.
Why this matters
- Findings reinforce the public message of the harmful effects of smoking and benefits of smoking cessation.
Study design
- This retrospective analysis compared short and intermediate mortality following PCI among never-smokers (n=4288), ex-smokers (n=4806) and current smokers (n=3562).
- Funding: None.
Key results
- The mean age (±standard deviation [SD]) was 57 (±11) years in current smokers vs 67 (±11) years in ex-smokers and 67 (±12) years in never-smokers (P<.001).
- The proportion of patients undergoing PCI for ACS was highest in current smokers (84.1%) vs ex-smokers (57.0%) and never-smokers (62.9%) (P<.0001).
- Compared with never-smokers, the adjusted ORs (95% CIs) for 30-day mortality were 1.60 (1.10-2.32) in current smokers and 0.98 (0.70-1.38) in ex-smokers.
- Compared with never-smokers, the adjusted HRs (95% CIs) for mortality between 30 days and 6 months were 1.03 (0.65-1.65) in current smokers and 1.19 (0.84-1.67) in ex-smokers.
Limitations
- Retrospective design.
- Lack of data on smoking intensity and duration of smoking cessation in ex-smokers.
This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.
