- In patients with acute ischaemic stroke, insulin resistance was associated with unfavourable clinical outcomes at 3 months without increasing the risk for early stroke recurrence or mortality.
Why this matters
- Therapies targeting insulin resistance can improve functional outcomes following ischaemic stroke.
- Study evaluated 4655 patients aged 70.3 years with acute ischaemic stroke between April 2009 and March 2015.
- Association of the homeostasis model assessment of insulin resistance (HOMA-IR) score with clinical outcomes at 3 months was evaluated.
- HOMA-IR score quintiles: ≤0.84, 0.85-1.22, 1.23-1.73, 1.74-2.68, ≥2.68.
- Funding: Japan Society for the Promotion of Science.
- The HOMA-IR score was associated with neurologic improvement (ORhighest vs lowest quintile, 0.68; P<.001 and poor functional outcome>highest vs lowest quintile, 2.02; P<.001>
- HOMA-IR was not associated with early (≤3 months) stroke recurrence or death.
- The associations were maintained in:
- nondiabetic patients: neurological improvement (ORhighest vs lowest quintile, 0.71; P=.002); functional outcomes (ORhighest vs lowest quintile, 2.16; P<.001>
- nonobese patients: neurological improvement (ORhighest vs lowest quintile, 0.71; P=.004); functional outcomes (ORhighest vs lowest quintile, 1.87; P<.001>
- Patients without HOMA-IR data were not included.
- Results may not be generalisable to other populations.