Subclinical hypothyroidism: high PRL common, tied to infertility

  • Sirohi T & al.
  • J Family Med Prim Care

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • A cross-sectional study utilizing electrochemiluminescence to measure serum prolactin (PRL) levels finds that 18% of patients with subclinical hypothyroidism (SCH) have hyperprolactinemia, which is found to be associated with infertility.

Why this matters

  • This study suggests that prolactin estimation should be routinely performed in patients with SCH.

Key results

  • 18% of patients with SCH had hyperprolactinemia (18.5% of females and 13.3% of males).
  • Serum thyroid-stimulating hormone levels and PRL levels were inversely correlated (P=.007).
  • Hyperprolactinemia was associated with higher prevalence of infertility compared with normoprolactinemia (47.6% vs 13.2%; P=.001).

Study design

  • 150 patients with SCH (90% female; 10% male) were analyzed for serum PRL levels and associations with infertility.
  • Funding: None.

Limitations

  • Cross-sectional study design.

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