- A cross-sectional study utilizing electrochemiluminescence to measure serum prolactin (PRL) levels finds that 18% of patients with subclinical hypothyroidism (SCH) have hyperprolactinemia, which is found to be associated with infertility.
Why this matters
- This study suggests that prolactin estimation should be routinely performed in patients with SCH.
- 18% of patients with SCH had hyperprolactinemia (18.5% of females and 13.3% of males).
- Serum thyroid-stimulating hormone levels and PRL levels were inversely correlated (P=.007).
- Hyperprolactinemia was associated with higher prevalence of infertility compared with normoprolactinemia (47.6% vs 13.2%; P=.001).
- 150 patients with SCH (90% female; 10% male) were analyzed for serum PRL levels and associations with infertility.
- Funding: None.
- Cross-sectional study design.