- Intake of sugar-sweetened beverages is linked to increased cardiovascular mortality risk.
- In women, risk is increased even with intake of ≥4 artificially sweetened drinks/day, but this intake is not associated with cancer mortality.
Why this matters
- The authors say people should choose water instead.
- An American Heart Association’s science advisory suggested that substituting artificially sweetened drinks was a way to start replacing sugar-sweetened beverages.
- 3,415,564 person-years of follow-up.
- Pooled adjusted HRs for total mortality at various levels of sugary drink consumption (95% CIs):
- 1-4/month: 1.01 (0.98-1.04).
- 2-6/week: 1.06 (1.03-1.09).
- ≥2/day: 1.21 (1.13-1.28; Ptrend<.0001>
- And for cardiovascular mortality:
- Adjusted HR for Ptrend<.0001.>
- For cancer mortality:
- Adjusted HR for Ptrend=.0004.
- With intake of artificially sweetened drinks, Ptrend values for cardiovascular and total mortality in the cohort of women were .02 and .0001, respectively.
- Data from Nurses’ Health Study (80,647 women) and Health Professional's Follow-up Study (37,716 men).
- 34 and 28 years of follow-up, respectively.
- Cox proportional hazards regression to estimate HRs.
- Funding: NIH.
- The usual limitations of observational studies.