- Regular consumption of sugar-sweetened beverages (SSBs) is associated with a more than 2-fold increased risk for breast cancer (BC) in postmenopausal, but not premenopausal, women.
Why this matters
- Postmenopausal women should be encouraged to restrict SSB consumption.
- Mechanistic link between SSB and BC may be through an SSB-induced increase in insulin resistance.
- Prospective cohort (n=10,713) of middle-aged women (median age, 33 years) without BC in the Seguimiento Universidad de Navarra (SUN) cohort.
- SSB at baseline assessed by food frequency questionnaire, with exposure stratified by "never/seldom" (
- Funding: Instituto de Salud Carlos III, Spain; European Regional Development Fund.
- 100 incident cases of BC were seen during 106,189 person-years of follow-up.
- Regular (vs never/seldom) SSB consumption in postmenopausal women was associated with a more than 2-fold increase in incident BC (adjusted HR, 2.12; 95% CI, 1.02-4.41).
- Regular (vs never/seldom) SSB consumption in premenopausal women was not associated with incident BC (adjusted HR, 1.16; 95% CI, 0.66-2.07).
- Small number of incident BCs.
- "Regular" exposure category too broad.
- Potential misclassification bias.