Sugary drinks tied to postmenopausal breast cancer in Spanish study

  • Romanos-Nanclares A & al.
  • Eur J Nutr
  • 3 Oct 2018

  • curated by Miriam Davis, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Regular consumption of sugar-sweetened beverages (SSBs) is associated with a more than 2-fold increased risk for breast cancer (BC) in postmenopausal, but not premenopausal, women.

Why this matters

  • Postmenopausal women should be encouraged to restrict SSB consumption.
  • Mechanistic link between SSB and BC may be through an SSB-induced increase in insulin resistance.

Study design

  • Prospective cohort (n=10,713) of middle-aged women (median age, 33 years) without BC in the Seguimiento Universidad de Navarra (SUN) cohort.
  • SSB at baseline assessed by food frequency questionnaire, with exposure stratified by "never/seldom" (
  • Funding: Instituto de Salud Carlos III, Spain; European Regional Development Fund.

Key results

  • 100 incident cases of BC were seen during 106,189 person-years of follow-up.
  • Regular (vs never/seldom) SSB consumption in postmenopausal women was associated with a more than 2-fold increase in incident BC (adjusted HR, 2.12; 95% CI, 1.02-4.41).
  • Regular (vs never/seldom) SSB consumption in premenopausal women was not associated with incident BC (adjusted HR, 1.16; 95% CI, 0.66-2.07).

Limitations

  • Small number of incident BCs.
  • "Regular" exposure category too broad.
  • Potential misclassification bias.

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