- Surgical resection for stage I small-cell lung cancer (SCLC) was associated with significantly longer OS and lung cancer-specific survival (LCSS) in elderly patients aged 75-84 years.
Why this matters
- Less than one-quarter of patients aged ≥75 years underwent surgery, despite guidelines’ recommendations for resection in early-stage SCLC.
- 983 patients aged ≥75 years with stage I SCLC from the Surveillance, Epidemiology, and End Results database.
- Funding: Changzhou Science and Technology Bureau.
- 24.0% underwent surgery, 46.6% nonsurgical treatment, and 29.4% had no treatment.
- Younger patients in the study were more likely to undergo surgery than older patients (29.3% in ages 75-79 years; 19.1% in ages 80-84 years; and 16.4% in patients aged ≥85 years; P<.0001>
- Surgery yielded significantly better 5-year OS (31% vs no surgery, 12% and no treatment, 6%; P<.0001 and lcss vs p>
- In multivariate analysis, surgery predicted OS and LCSS benefit in patients aged:
- 75-79 years (aHR, 0.506 and 0.449, both P<.0001>
- 80-84 years (aHR, 0.544 [P<.0001 and>
- Retrospective study.