T2Bacteria panel quickly identifies common bloodstream infections

  • Nguyen MH et al
  • Ann Intern MEd
  • 13 May 2019

  • International Clinical Digest
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  • The T2Bacteria panel quickly and accurately identifies (or excludes) bloodstream infections (BSIs) caused by 5 common bacterial species (aka ESKAPE: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli).
  • Related editorial.

Why this matters

  • T2Bacteria panel may improve BSI, sepsis management, providing timely results vs blood culture.
  • Use in conjunction with blood, nonblood cultures and interpret results carefully based on patient clinical status, antibiotic use.

Key results

  • 1427 samples.
  • Results concordant with blood culture in 90% (1277) of samples, discordant in 10% (150).
  • Mean time to results ranged from 3.61 (standard deviation [SD], 0.2; 1 sample) to 7.70 hours (SD, 1.38; 7 samples).
  • Sensitivity for proven BSI: 90% (95% CI, 76%-96%).
  • 20% (7/35) of patients with T2/culture concordant samples received an appropriate antibiotic at the time of sample collection, and 80% (25/31) received one in ≤24 hours.
  • Overall per-patient, per-assay specificities: 90% (1242/1388; 95% CI, 88%-91%), 98% (6941/7096; 95% CI, 97%-98%), respectively.

Study design

  • Prospective, multicenter study assessing T2Bacteria panel performance in identifying 5 target bacteria among hospitalized patients with blood cultures ordered as standard of care.
  • Funding: T2 Biosystems.


  • Low prevalence of positive blood cultures for targeted organisms.
  • Only 1 set of aerobic, anaerobic specimens for companion blood culture.
  • Detection limited to 5 bacterial species.

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