- The T2Bacteria panel quickly and accurately identifies (or excludes) bloodstream infections (BSIs) caused by 5 common bacterial species (aka ESKAPE: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli).
- Related editorial.
Why this matters
- T2Bacteria panel may improve BSI, sepsis management, providing timely results vs blood culture.
- Use in conjunction with blood, nonblood cultures and interpret results carefully based on patient clinical status, antibiotic use.
- 1427 samples.
- Results concordant with blood culture in 90% (1277) of samples, discordant in 10% (150).
- Mean time to results ranged from 3.61 (standard deviation [SD], 0.2; 1 sample) to 7.70 hours (SD, 1.38; 7 samples).
- Sensitivity for proven BSI: 90% (95% CI, 76%-96%).
- 20% (7/35) of patients with T2/culture concordant samples received an appropriate antibiotic at the time of sample collection, and 80% (25/31) received one in ≤24 hours.
- Overall per-patient, per-assay specificities: 90% (1242/1388; 95% CI, 88%-91%), 98% (6941/7096; 95% CI, 97%-98%), respectively.
- Prospective, multicenter study assessing T2Bacteria panel performance in identifying 5 target bacteria among hospitalized patients with blood cultures ordered as standard of care.
- Funding: T2 Biosystems.
- Low prevalence of positive blood cultures for targeted organisms.
- Only 1 set of aerobic, anaerobic specimens for companion blood culture.
- Detection limited to 5 bacterial species.