Takeaway
- Patients with insulin resistance (IR) and newly diagnosed type 2 diabetes (T2D) were more likely to develop heart failure (HF) or die than those who were sensitive to insulin.
- This association was independent of different body mass index categories.
Why this matters
- Findings suggest that homoeostasis model assessment 2-IR (HOMA2-IR) measured at the time of T2D diagnosis may be an important additional predictor of the future risk of HF and death in patients with T2D.
Study design
- A post hoc analysis of the UK Prospective Diabetes Study (UKPDS) included 5102 participants with newly diagnosed T2D.
- Insulin resistance (HOMA2-IR) values were obtained from paired fasting plasma glucose and insulin measures.
- Primary outcome: composite of incident HF or death.
- Funding: Oxfordshire Health Services Research Committee grant.
Key results
- Of 5102 UKPDS participants with newly diagnosed T2D, 2099 had HOMA2-IR <1.6 and 2245 had HOMA2-IR ≥1.6.
- Over a median follow-up of 16.4 years, the composite of HF/death outcomes was reported in 1974 (45.4%) participants (235 first HF events and 1739 deaths), corresponding to an incidence rate of 29.6 per 1000 person-years.
- A 2-fold increase in HOMA2-IR was associated with (adjusted relative risk [aRR]; 95% CI):
- 5% greater risk of HF/death (1.05; 1.01-1.12; P=.0029); and
- 14% greater risk of HF (1.14; 1.02-1.27; P=.017).
- No heterogeneity was observed for the association of HOMA2-IR with HF/death between normal-weight, overweight, and obese individuals (Pinteraction=.16).
- Over 5 years, The Kaplan-Meier survival analysis showed no between-group differences in HF event/death in participants randomly assigned to:
- a conventional glycaemic control strategy with diet (reference group); and
- an intensive glucose control strategy with (RR; 95% CI):
- sulphonylurea (0.96; 0.90-1.02);
- insulin (0.94; 0.88-1.01); and
- metformin (0.92; 0.83-1.02; log-rank P=.24).
Limitations
- Post hoc analysis.
This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.