- Patients with tonsillitis are at an increased risk of developing ankylosing spondylitis (AS).
- The association between tonsillitis and AS is stronger in patients with higher severity of tonsillitis or a longer interval between AS and diagnosis of tonsillitis.
Why this matters
- Findings suggest that tonsillitis may trigger a gradual exacerbation of inflammation in patients with AS.
- This population-based case-control study included 37,002 newly diagnosed AS patients and 222,012 age-, sex- and index year-matched (1:6) non-AS controls.
- Funding: Taichung Veterans General Hospital, Taiwan.
- Patients with AS vs non-AS controls were more likely to have:
- tonsillitis (45.5% vs 36.2%; aOR, 1.46; 95% CI, 1.43-1.50; P<.001>
- appendicitis (0.7% vs 0.5%; aOR, 1.29; 95% CI, 1.13-1.48; P<.001 and>
- periodontitis (29.0% vs 22.8%; aOR, 1.35; 95% CI, 1.31-1.38; P<.001>
- >4 visits for tonsillitis (aOR, 1.82; 95% CI, 1.75-1.89), and
- ≥5.4 years interval between tonsillitis and AS (aOR, 1.84; 95% CI, 1.76-1.91).
- Causal link between tonsillitis and newly diagnosed AS could not be determined.
- Clinical severity of tonsillitis was not assessed.