- Surgical sterilization is not associated with risk for early menopause.
Why this matters
- Surgical sterilization, through tubal occlusion or salpingectomy, is one of the most common methods of contraception in the United States.
- Tubal ligation is associated with a decreased risk for ovarian cancer, which led to a suspicion of a long-term effect on ovarian function.
- Mean age of natural menopause was 50.0 years.
- No difference in age of natural menopause in women with tubal ligation compared with those without tubal ligation.
- Type of surgical procedure did not affect age at menopause.
- Cross-sectional study using 3 preexisting cohorts:
- Cohort 1: women with history of oophorectomy prior to age 50 years (n=555),
- Cohort 2: women aged ≥30 years who enrolled in the Mayo Clinic Biobank (n=1816),
- Cohort 3: women aged ≥35 years seen at the Mayo Clinic for mammography (n=1534).
- History of tubal ligation compared with age at natural menopause.
- Funding: NIH.
- Relied on self-reporting for age of menopause.
- Women with salpingectomies for reasons other than sterilization included.