- Risks for colorectal cancer (CRC) and CRC mortality are higher in patients with ulcerative colitis (UC).
Why this matters
- Previous estimates were based on older treatment and surveillance regimens.
- Previous studies used incident CRC cases and were thus subject to surveillance and lead-time bias.
- A population-based cohort study of 96,447 patients with UC and 949,207 unaffected individuals in Sweden and Denmark (1969-2017).
- Funding: Various nonindustry sources.
- Patients with UC had 1.29 incident CRCs per 1000 person-years vs 0.82 in the reference population (aHR, 1.66; 95% CI, 1.57-1.76).
- Patients with UC had 0.55 CRC-related deaths per 1000 person-years vs 0.38 among the reference population (aHR, 1.59; 95% CI, 1.46-1.72).
- Overall, patients with UC with CRC were diagnosed with less advanced disease (P<.0001 but had greater risk for crc death when tumor stage at diagnosis was controlled ci>
- Although the excess risk associated with UC declined over time, in the final 5 years of follow-up, it remained heightened:
- Incidence: HR, 1.38 (95% CI, 1.20-1.60).
- CRC mortality: HR, 1.25 (95% CI, 1.03-1.51).
- No data on lifestyle factors.