Takeaway
- Among patients with overweight and obesity and moderate-severe obstructive sleep apnoea syndrome (OSAS), 66% had diabetes mellitus (DM) or glucose intolerance (GIT) and 43% (28% overall) were not previously diagnosed.
- Patients with moderate-to-severe OSAS should be screened for dysglycemia.
Why this matters
- Untreated diabetes can lead to serious complications.
Study design
- Prospective evaluation of 280 patients with moderate or severe OSAS referred for continuous positive airway pressure (CPAP) therapy.
- Funding: None disclosed.
Key results
- Diabetes was present in 22% and GIT in 44%.
- Among these 183 patients, 34% were already taking oral or subcutaneous glucose-lowering medication.
- Among those 62 treated patients, GIT was present in 18 (29%).
- Undiagnosed DM or GIT accounted for 28% of the 280 patients.
- Insulin resistance was present in 44% of patients.
- Most (73%) had severe OSAS, and those patients were more obese and exhibited higher glucose and C-peptide levels.
- DM and GIT prevalence was not associated with OSAS severity.
- In multivariate analysis, BMI, male sex, and insulin resistance were significantly associated with OSAS severity.
Limitations
- No age-, sex-, and BMI-matched non-OSAS healthy control group.
- All patients were at least overweight.
- No adjustment for confounding factors.
- Blood sampling done after 1 single CPAP treatment night.
References
References
