- The risk for cardiovascular disease (CVD), including ischaemic heart disease and heart failure, and mortality was higher among patients with concentrations of 25-hydroxyvitamin D [25(OH)D]
Why this matters
- Findings call for future large clinical trials that include a large number of vitamin D insufficient participants to evaluate the effects of vitamin D supplementation on CVD.
- Longitudinal analysis of 180,263 patients (aged ≥18 years) without a history of CVD and with circulating concentrations of 25(OH)D from The Health Improvement Network (THIN) primary care database collected during 2005-2016.
- Funding: None.
- Overall, 3747 patients were diagnosed with CVD and 3912 patients died at a mean follow-up of 2.2 years.
- Patients with lowest 25(OH)D quintile (
- CVD (HR, 1.24; 95% CI, 1.12-1.38; P<.001 and>
- mortality (HR, 1.71; 95% CI, 1.55-1.88).
- ischaemic heart disease (HR, 1.35; 95% CI, 1.13-1.60; P=.001) and
- heart failure (HR, 1.38; 95% CI, 1.08-1.77; P=.026).
- Risk for residual confounding.