Vitamin D and risk for cardiovascular disease and mortality

  • Crowe FL & al.
  • J Steroid Biochem Mol Biol
  • 18 Sep 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • The risk for cardiovascular disease (CVD), including ischaemic heart disease and heart failure, and mortality was higher among patients with concentrations of 25-hydroxyvitamin D [25(OH)D]

Why this matters

  • Findings call for future large clinical trials that include a large number of vitamin D insufficient participants to evaluate the effects of vitamin D supplementation on CVD.

Study design

  • Longitudinal analysis of 180,263 patients (aged ≥18 years) without a history of CVD and with circulating concentrations of 25(OH)D from The Health Improvement Network (THIN) primary care database collected during 2005-2016.
  • Funding: None.

Key results

  • Overall, 3747 patients were diagnosed with CVD and 3912 patients died at a mean follow-up of 2.2 years.
  • Patients with lowest 25(OH)D quintile (
  • CVD (HR, 1.24; 95% CI, 1.12-1.38; P<.001 and>
  • mortality (HR, 1.71; 95% CI, 1.55-1.88).
  • The increased risk for CVD among patients with the lowest 25(OH)D quintile was more from:
    • ischaemic heart disease (HR, 1.35; 95% CI, 1.13-1.60; P=.001) and
    • heart failure (HR, 1.38; 95% CI, 1.08-1.77; P=.026).           
  • Limitations

    • Risk for residual confounding.