- Vitamin D supplementation might offer some lipid profile benefit in patients with hypercholesterolemia and vitamin D insufficiency who are at increased risk for cardiovascular disease (CVD).
- This meta-analysis found decreased serum total and low-density lipoprotein cholesterol (LDL-C) and triglycerides with supplementation.
Why this matters
- Vitamin D’s once promising reputation as a supplement has taken some hits, with limited CVD-related benefits recently reported.
- In a specific patient population, perhaps it has something to offer.
- For each lipid measure, standardized mean differences (95% CIs) for change from baseline to follow-up between placebo and supplement were:
- Total cholesterol: −0.17 (−0.28 to −0.06).
- LDL-C: −0.12 (−0.23 to −0.01).
- Triglycerides: −0.12 (−0.25 to 0.01).
- High-density lipoprotein cholesterol: −0.19 (−0.44 to 0.06; not significant).
- Greater benefit seen in patients who had existing vitamin D insufficiency.
- Because of some heterogeneity scores, the authors removed some studies that appeared to be outliers but got similar results.
- In one further analysis of triglyceride results because of implied publication bias, the effect disappeared.
- Supplementation effects appeared to wane with time in a comparison of trial durations ≤6 months vs >6 months.
- Meta-analysis, 41 randomized controlled trials, total 3434 participants.
- Funding: None.
- Short follow-up in most included trials.