Vitamin D3 supplements help reverse early cervical neoplasia

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  • Supplementation with vitamin D3 administered for 6 mo resulted in regression of cervical intraepithelial neoplasia grade 1 (CIN-1) and also improved glucose homeostasis parameters.
Why this matters
  • These findings suggest that vitamin D3 supplementation can benefit women with CIN-1.
Study design
  • Randomized, placebo-controlled trial composed of 58 women diagnosed with CIN1; cohort was randomly assigned to 50,000 IU vitamin D3 supplements (n=29) or placebo (n=29), taken every 2 wk for 6 mo.
  • Funding: Vice-chancellor for Research, KUMS, and Iran.
Key results
  • A higher percentage in the vitamin D group showed regression of CIN1 (84.6% vs 53.8%; P=.01) vs placebo.
  • The vitamin D group showed a significant decrease in serum insulin levels (−5.3±7.3 vs +2.4±5.9 μIU/mL; P<.001), insulin resistance (−1.2±1.6 vs +0.5±1.2; P<.001), and β-cell function (P=.005), and a significant rise in quantitative insulin sensitivity check index (+0.03±0.04 vs −0.007±0.02; P<.001).
  • Significant increases in plasma nitric oxide were also noted (+15.5±10.3 vs +4.0±13.4 μmol/L; P=.001).
  • Unable to assess the effect of vitamin D supplementation on HPV.