Vitamin D3 supplements help reverse early cervical neoplasia

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  • Supplementation with vitamin D3 administered for 6 mo resulted in regression of cervical intraepithelial neoplasia grade 1 (CIN-1) and also improved glucose homeostasis parameters.
Why this matters
  • These findings suggest that vitamin D3 supplementation can benefit women with CIN-1.
Study design
  • Randomized, placebo-controlled trial composed of 58 women diagnosed with CIN1; cohort was randomly assigned to 50,000 IU vitamin D3 supplements (n=29) or placebo (n=29), taken every 2 wk for 6 mo.
  • Funding: Vice-chancellor for Research, KUMS, and Iran.
Key results
  • A higher percentage in the vitamin D group showed regression of CIN1 (84.6% vs 53.8%; P=.01) vs placebo.
  • The vitamin D group showed a signific...