- Results from a small randomized clinical trial suggest that transplanting a combination of noncultured dermal and epidermal cell suspensions (NDCS+NCES) is associated with higher repigmentation rates vs NCES alone in patients with short duration of clinical stability (DS; 3-6 months).
Why this matters
- Pilot study suggests that dermal mesenchymal stem cells from NDCS might improve efficacy of NCES.
- In patients with DS of 3-6 months, NDCS+NCES was associated with a higher rate of >75% repigmentation at 24 weeks compared with NCES alone (100% vs 30%; P=.003).
- In patients with DS >12 months, NDCS+NCES and NCES alone were associated with similar rates of >75% repigmentation at 24 weeks (60% vs 70%; P>.99).
- 40 patients with focal, segmental, or generalized vitiligo were included.
- 20 patients had DS of 3-6 months; 20 patients had DS >12 months.
- Within each clinical stability subgroup, 10 patients received NDCS+NCES and 10 patients received NCES alone.
- Funding: None disclosed.
- Small sample size.