- In patients who have heart failure (HF) and coronary artery disease (CAD), the optimal systolic BP appears to be 120-140 mmHg and the optimal heart rate
Why this matters
- The optimal window for systolic BP and heart rate in this patient group has been elusive.
- Mean follow-up was 2.5 years. Having HF vs not having HF with CAD was tied to increased risk for the primary outcome (composite of all-cause death, first myocardial infarction, stroke): HR, 2.55 (95% CI, 2.30-2.83).
- Similar risks were found for each primary outcome component separately.
- With history of HF, a systolic BP 140 mmHg was tied to worse outcomes.
- Drug choice for treating hypertension was not associated with the primary outcome.
- A heart rate ≥85 bpm was also tied to worse outcomes.
- Data were analyzed for 1256 patients with HF, a subcohort from the multicenter INternational VErapamil SR-Trandolapril Study (n=22,576 CAD patients).
- Funding: BASF Pharma; Abbott Laboratories; University of Florida Research Foundation and Opportunity Fund.
- Patients with most severe HF were excluded.
- No data on left ventricular ejection fraction.