- Anti-Müllerian hormone (AMH) levels are a better predictor of live birth rate than follicle-stimulating hormone (FSH) levels when test results are discordant in women undergoing in vitro fertilization (IVF).
Why this matters
- FSH and AMH levels are discordant in 20%-43% of patients, and their relative utility for live birth prediction is controversial.
- In the overall cohort, the live birth rate was 38%.
- In patients with low AMH and normal FSH (n=6611), the live birth rate was 26%, whereas in patients with normal AMH and elevated FSH (n=4374), the live birth rate was 39% (P<.001>
- Patients with low AMH/normal FSH had greater IVF cycle cancellation rates compared with patients with normal AMH/elevated FSH (19% vs 8%; P<.001>
- In patients with normal FSH, low AMH was associated with reduced live birth (relative risk, 0.87; P<.001 compared with normal amh in multivariate analysis.>
- 44,696 patients who underwent fresh embryo transfer were analyzed for live birth rates and associated factors.
- Elevated FSH was defined as >10 mIU/mL, whereas low AMH was defined as
- Funding: None disclosed.
- Retrospective study.