Why do some people itch after postcesarean analgesia?

  • Tan X & al.
  • Medicine (Baltimore)
  • 1 Oct 2019

  • International Clinical Digest
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Epidural morphine-induced pruritus (EMIP) affected 18.6% of the population in this study and was associated with a history of allergy and not using serotonin receptor antagonists.

Why this matters

  • Women often complain about pruritus after epidural administration.
  • Pruritus can be a troublesome side effect, and little is known about its incidence or how to relieve it.

Key results

  • 18.6% of the cohort reported EMIP.
  • Patients with pruritus reported itching around face, trunk, upper limbs, lower limbs, or throughout the body.
  • The itching emerged 5.6±4.8 hours after morphine administration and lasted for 14.0±8.8 hours.
  • Visual Analogue Scale (VAS) scores were not significantly different in women with EMIP compared with the no-EMIP group.
  • Risk factors for EMIP included history of allergy (P<.001 not using a serotonin receptor antagonist>

Study design

  • Prospective, multicentre, observational study.
  • Participants having elective cesarean delivery were invited to participate (n=284).
  • Epidural morphine (2-3 mg) was administered after delivery and before the end of the operation.
  • Primary outcome was incidence of EMIP.
  • Funding: Tibet Natural Science Funding Committee Grant; CAMS Innovation Fund for Medical Sciences.

Limitations

  • Results may not be generalisable; population mainly of Asian ancestry.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit