Women with polycystic ovary syndrome are at increased for obstructive sleep apnoea

  • Balachandran K & al.
  • Eur J Endocrinol
  • 1 Feb 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • Women with polycystic ovary syndrome (PCOS) are at increased risk of developing obstructive sleep apnoea (OSA) compared with women without PCOS irrespective of obesity.

Why this matters

  • Clinicians treating women with PCOS should have a low threshold to test for OSA.
  • Findings suggest that clinical features of hyperandrogenism and low progesterone may increase the risk for OSA in women with PCOS.

Study designs

  • This population-based retrospective cohort study included 76,978 women with PCOS (age, 18-50 years) and 143,077 age-, body mass index (BMI)- and location-matched women without PCOS from 763 general practices using The Health Improvement Network (THIN).
  • Funding: National Institute for Health Research.

Results

  • The incidence of OSA was significantly higher in women with PCOS vs control group (8.1 vs 3.3 per 10,000 person-years of follow-up; HR, 2.46; P<.0001>
  • Women with PCOS were at increased risk for OSA vs control group (adjusted HR [aHR], 2.46; P<.001>
  • After adjustment for confounders, the risk for OSA was higher in women with PCOS vs control group (aHR, 2.26; P<.001>
  • Compared with the control group, the risk for OSA was higher in normal weight (BMI 2: HR, 1.91; P=.081, overweight (BMI 25-29.99 kg/m2: HR, 2.25; P=.003) and obese (BMI ≥30 kg/m2: HR, 2.10; P<.001 women with pcos.>

Limitations

  • Results may not be generalised to patients with a milder form of the disease.

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